Detailed results from the IXORA-S study have revealed that Taltz (ixekizumab) has superior efficacy compared to Stelara (ustekinumab). According to Eli Lilly and Co (NYSE:LLY) and Company, patients treated for moderate-to-severe plaque psoriasis with the former had better response results at 24 weeks unlike those who used the latter.
The results included 83% of patients who obtained a Psoriasis Area Severity Index (PASI) score of 90. This was much higher than the 59% of patients who obtained a PASI of 90 after having Stelara administered in them.
Introduction of treatments like Taltz will offer more treatment options
Taltz could be significant in that it could offer patients who are seeking to achieve PASI 90 or PASI 100 with treatment options. The lead author of the study, Kristian Reich says, “For many years, achieving PASI 75 – or 75 percent improvement in skin plaques – has been the standard treatment goal for moderate-to-severe plaque psoriasis.”
The results of the IXORA-S study, which were presented at the the American Academy of Dermatology (AAD) Annual Meeting were steady with pivotal Phase 3 trials. The study involved randomized patients who received either 45 mg or 90 mg of Stelara or 80 mg of Taltz administered very two weeks for 12 weeks and another 80 mg every four weeks.
There were notable cases of adverse events even though they were not so severe. Taltz, which was endorsed in the U.S., Canadadian, and European health agencies almost one year ago, displayed consistency with previous clinical trials in its safety profile.
However, there are precautions to observe. It is likely that the treatment may have a higher risk of infection and severe infections have occurred previously. Hence it is advisable that every user seek guidance from a physician in the event of an acute infection.
Nonetheless, to this point, Eli Lilly’s global brand development leader, Dr. Lotus Mallbris says that they are happy with the new results because it will enhance the clinical benefits of Taltz. Meanwhile, Eli Lilly’s stock closed at $83.83 witnessing an increase of 0.05 or 0.06%.